Endocrine Abstracts

Objective: Type 2 diabetes mellitus (T2DM) patients have a higher risk for bone fractures, especially in the elderly. However, bone mineral density (BMD) does not reflect their increased bone fragility, potentially based on disturbed bone metabolism or quality. MicroRNAs are promising new biomarkers for fracture risk detection. This study aimed to find specific miRNAs in a large cohort of elderly patients with and without T2DM at risk for osteoporotic fractures.<p class="a...

Introduction: Soluble ST2 (sST2) is the truncated soluble form of the ST2 receptor in the circulation. It is a decoy receptor of IL-33 and thereby inhibits the effects of IL-33/ST2 signaling. Elevated levels of sST2 have been associated with various adverse cardiovascular outcomes. Recently, potential associations of sST2 with obesity and type 2 diabetes mellitus (T2DM) have been described in the general population. In this study, we determined possible cross-sectional associa...